Block PAM.

Unlock tomorrow.

Harnessing the potential of the PAM (PI3K/AKT/mTOR) pathway to improve outcomes forthose affected by cancer.

PAM Pathway

Overactivation of the PAM (PI3K/AKT/mTOR) pathway plays a key role in the progression of a wide variety of human cancers.

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REVTORPYK™ (gedatolisib) is FDA-approved as a 2nd-line treatment for HR+/HER2-PIK3CA wild-type advanced breast cancer.

Scientist looking through microscope

Our Pipeline

We are evaluating gedatolisib across a range of solid tumors to improve patient outcomes.

Scientist looking through microscope

Clinical Trials

We have multiple ongoing clinical trials for gedatolisib as a potential treatment for breast and prostate cancer.

Patient Advocacy

Job Openings